1,151 research outputs found
Cycle-time properties of the timed token medium access control protocol
We investigate the timing properties of the timed token protocol that are necessary to guarantee synchronous message deadlines. A tighter upper bound on the elapse time between the token's lth arrival at any node i and its (l + v)th arrival at any node k is found. A formal proof to this generalized bound is presented
On the flow-level stability of data networks without congestion control: the case of linear networks and upstream trees
In this paper, flow models of networks without congestion control are
considered. Users generate data transfers according to some Poisson processes
and transmit corresponding packet at a fixed rate equal to their access rate
until the entire document is received at the destination; some erasure codes
are used to make the transmission robust to packet losses. We study the
stability of the stochastic process representing the number of active flows in
two particular cases: linear networks and upstream trees. For the case of
linear networks, we notably use fluid limits and an interesting phenomenon of
"time scale separation" occurs. Bounds on the stability region of linear
networks are given. For the case of upstream trees, underlying monotonic
properties are used. Finally, the asymptotic stability of those processes is
analyzed when the access rate of the users decreases to 0. An appropriate
scaling is introduced and used to prove that the stability region of those
networks is asymptotically maximized
Gene Expression of Human Lung Cancer Cell Line CL1-5 in Response to a Direct Current Electric Field
Background: Electrotaxis is the movement of adherent living cells in response to a direct current (dc) electric field (EF) of physiological strength. Highly metastatic human lung cancer cells, CL1-5, exhibit directional migration and orientation under dcEFs. To understand the transcriptional response of CL1-5 cells to a dcEF, microarray analysis was performed in this study. Methodology/Principal Findings: A large electric-field chip (LEFC) was designed, fabricated, and used in this study. CL1-5 cells were treated with the EF strength of 0mV/mm (the control group) and 300mV/mm (the EF-treated group) for two hours. Signaling pathways involving the genes that expressed differently between the two groups were revealed. It was shown that the EF-regulated genes highly correlated to adherens junction, telomerase RNA component gene regulation, and tight junction. Some up-regulated genes such as ACVR1B and CTTN, and some down-regulated genes such as PTEN, are known to be positively and negatively correlated to cell migration, respectively. The protein-protein interactions of adherens junction-associated EF-regulated genes suggested that platelet-derived growth factor (PDGF) receptors and ephrin receptors may participate in sensing extracellular electrical stimuli. We further observed a high percentage of significantly regulated genes which encode cell membrane proteins, suggesting that dcEF may directly influence the activity of cell membrane proteins in signal transduction. Conclusions/Significance: In this study, some of the EF-regulated genes have been reported to be essential whereas others are novel for electrotaxis. Our result confirms that the regulation of gene expression is involved in the mechanism of electrotactic response
Quasi-particle model for lattice QCD: quark-gluon plasma in heavy ion collisions
We propose a quasi-particle model to describe the lattice QCD equation of
state for pure SU(3) gauge theory in its deconfined state, for .
The method involves mapping the interaction part of the equation of state to an
effective fugacity of otherwise non-interacting quasi-gluons. We find that this
mapping is exact. Using the quasi-gluon distribution function, we determine the
energy density and the modified dispersion relation for the single particle
energy, in which the trace anomaly is manifest. As an application, we first
determine the Debye mass, and then the important transport parameters, {\it
viz}, the shear viscosity, and the shear viscosity to entropy density
ratio, . We find that both and
are sensitive to the interactions, and that the interactions significantly
lower both and .Comment: 10 pages, 8 figures, epj class file, version accepted for publication
in Euro. Phys.J
Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level
Tumors infected with a recombinant defective adenovirus expressing interleukin 12 (IL-12) undergo regression, associated with a cytotoxic T lymphocyte (CTL)-mediated antitumor immune response. In the present study we generated anti-CT26 CTLs by short-term coculture of CT26 cells and lymph node cells obtained from mice harboring subcutaneous CT26 tumors injected with an adenoviral vector expressing IL-12 (AdCMVIL-12), control adenovirus (AdCMVlacZ), or saline. Regression of small intrahepatic CT26 tumors in unrelated syngeneic animals was achieved with CTLs derived from mice whose subcutaneous tumors had been injected with AdCMVIL-12 but not with CTLs from the other two control groups. The necessary and sufficient effector cell population for adoptive transfer consisted of CD8+ T cells that showed anti-CT26 specificity partly directed against the AH1 epitope presented by H-2Ld. Interestingly, treatment of a subcutaneous tumor nodule with AdCMVIL-12, combined with intravenous adoptive T cell therapy with short-term CTL cultures, had a marked synergistic effect against large, concomitant live tumors. Expression of IL-12 in the liver in the vicinity of the hepatic tumor nodules, owing to spillover of the vector into the systemic circulation, appeared to be involved in the increased in vivo antitumor activity of injected CTLs. In addition, adoptive T cell therapy improved the outcome of tumor nodules transduced with suboptimal doses of AdCMVIL-12. Our data provide evidence of a strong synergy between gene transfer of IL-12 and adoptive T cell therapy. This synergy operates both at the induction and effector phases of the CTL response, thus providing a rationale for combined therapeutic strategies for human malignancies
Measurement of the Branching Fraction for B->eta' K and Search for B->eta'pi+
We report measurements for two-body charmless B decays with an eta' meson in
the final state. Using 11.1X10^6 BBbar pairs collected with the Belle detector,
we find BF(B^+ ->eta'K^+)=(79^+12_-11 +-9)x10^-6 and BF(B^0 ->
eta'K^0)=(55^+19_-16 +-8)x10^-6, where the first and second errors are
statistical and systematic, respectively. No signal is observed in the mode B^+
-> eta' pi^+, and we set a 90% confidence level upper limit of BF(B^+->
eta'pi^+) eta'K^+- decays is
investigated and a limit at 90% confidence level of -0.20<Acp<0.32 is obtained.Comment: Submitted to Physics Letters
Recent Developments in Modeling Heteroepitaxy/Heterogeneous Nucleation by Dynamical Density Functional Theory
Crystallization of supersaturated liquids usually starts by epitaxial growth or by heterogeneous
nucleation on foreign surfaces. Herein, we review recent advances made in modeling
heteroepitaxy and heterogeneous nucleation on flat/modulated surfaces and nanoparticles
within the framework of a simple dynamical density functional theory, known as the phase-field
crystal model. It will be shown that the contact angle and the nucleation barrier are nonmonotonous
functions of the lattice mismatch between the substrate and the crystalline phase.
In continuous cooling studies for substrates with lattice mismatch, we recover qualitatively the
Matthews–Blakeslee mechanism of stress release via the misfit dislocations. The simulations
performed for particle-induced freezing will be confronted with recent analytical results,
exploring thus the validity range of the latter. It will be demonstrated that time-dependent
studies are essential, as investigations based on equilibrium properties often cannot identify the
preferred nucleation pathways. Modeling of these phenomena is essential for designing materials
on the basis of controlled nucleation and/or nano-patterning
Observation of the Decays B0->K+pi-pi0 and B0->rho-K+
We report the observation of B^0 decays to the K^+pi^-pi^0 final state using
a data sample of 78 fb^-1 collected by the Belle detector at the KEKB e^+e^-
collider. With no assumptions about intermediate states in the decay, the
branching fraction is measured to be (36.6^{+4.2}_{-4.3}+- 3.0)*10^-6.We also
search for B decays to intermediate two-body states with the same K^+pi^-pi^0
final state. Significant B signals are observed in the rho(770)^- K^+ and
K^*(892)^+pi^- channels, with branching fractions of
(15.1^{+3.4+1.4+2.0}_{-3.3-1.5-2.1})* 10^-6 and
(14.8^{+4.6+1.5+2.4}_{-4.4-1.0-0.9})* 10^-6, respectively. The first error is
statistical, the second is systematic and the third is due to the largest
possible interference. Contributions from other possible two-body states will
be discussed. No CP asymmetry is found in the inclusive K^+pi^-pi^0 or rho^-K^+
modes, and we set 90% confidence level bounds on the asymmetry of
-0.12<A_{CP}<0.26 and -0.18<A_{CP}<0.64, respectively.Comment: 18 pages, 7 figure
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